The San Francisco 49ers and Denver Broncos will meet on Sunday Night Football. Kickoff in Denver is set for 8:20 p.m. ET. The 49ers are favored by 1.5 points in the latest 49ers vs. Broncos odds from Caesars Sportsbook, while the over/under is 45. Before you make any 49ers vs. Broncos picks or any other NFL predictions, you NEED to see which side Tom Fornelli is on. 

The CBS national writer went a profitable 29-16-1 in his last 46 NFL best bets. What's more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 17-6 on picks involving San Francisco. Anyone who has followed him is WAY UP!

The expert knows the 49ers are dominating on defense to begin the 2022 season. San Francisco leads the NFL in total defense, giving up 210 yards per game, and is yielding only 13 points per outing. The 49ers also lead the league in first downs allowed and passing yards allowed, with top-five marks in points allowed per drive, passing touchdowns allowed, rushing yards allowed, and yards per carry allowed. 

The expert also knows the Broncos have been frisky on defense. Denver is also giving up fewer than 14 points per game and only 1.37 points per drive. Denver is No. 3 in the league in total defense and in the top eight in first downs allowed, passing yards allowed, and rushing yards allowed.

Now, Fornelli has locked in another confident against the spread pick for 49ers vs. Broncos. We can tell you he's leaning Under the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins 49ers vs. Broncos on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the 49ers vs. Broncos spread to jump on, all from the expert who's an outstanding 17-6 on San Francisco picks!