The seventh-seeded Denver Broncos will make their first postseason appearance since winning Super Bowl 50 when they take on the second-seeded Buffalo Bills on Sunday. Buffalo is making its sixth consecutive playoff appearance, but has not gotten past the divisional round since losing in the AFC Championship Game to the Kansas City Chiefs during the 2020 season. The Broncos (10-7), who placed third in the AFC West, were 4-5 on the road this year. The Bills (13-4), who won their fifth AFC East title in a row, were 8-0 on their home field.

Kickoff from Highmark Stadium in Orchard Park, NY, is set for 1 p.m. ET. Buffalo is an 8.5-point favorite in the latest Broncos vs. Bills odds, while the over/under for total points scored is 46.5. According to SportsLine consensus odds, the Bills are -446 money-line favorites (risk $446 to win $100), while the Broncos are +346 underdogs (risk $100 to win $346). Before making any Broncos vs. Bills bets or NFL predictions, you NEED to see which side SportsLine NFL expert Matt Severance is on, considering his mastery of picks involving the Broncos.

Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. He went 121-93-2 for a profit of $589 on his NFL spread picks last season. In fact, he is an AMAZING 25-7 (+1567) on his last 32 picks in games involving Denver! Anybody following him could be way up!

Now, Severance has locked in another confident against-the-spread pick for Broncos vs. Bills.

We can tell you he's leaning Under the point total, but he knows a crucial X-factor makes one side of the spread a must-back! You absolutely need to see what it is before locking in any picks of your own.

So who wins Broncos vs. Bills on NFL Wild Card Weekend, and what x-factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the Broncos vs. Bills spread to back, all from the expert who is a blistering 25-7 on picks involving the Broncos!