The Week 10 college football schedule is highlighted by a top-five matchup between Penn State and Ohio State. The No. 3 Nittany Lions are 3.5-point home underdogs, per the Week 10 college football odds, against the fourth-ranked Buckeyes, in what's one of two ranked contests of this week's slate. The other is No. 18 Pittsburgh vs. No 20 SMU, with the Mustangs favored by 7.5 points. There are several other intriguing games to make Week 10 college football bets on including Army vs. Air Force (+22.5), Oregon vs. Michigan (+15.5) and Georgia vs. Florida (+16.5).

SportsLine's college football experts and advanced computer model have analyzed the entire Week 10 college football schedule and revealed the top college football picks, college football betting trends, college football best bets, and more. If you're not already a subscriber, join SportsLine here to get everything you need to crush your Week 10 college football picks!