Week 12 of the 2024 NFL season offers a handful of intriguing matchups. The Detroit Lions visit the Indianapolis Colts with Detroit looking to continue its winning ways, but injuries on defense and the sudden reemergence of Colts quarterback Anthony Richardson could make this game much closer than it initially appears. The Arizona Cardinals and Seattle Seahawks do battle in the Pacific Northwest, with the NFC West still totally up for grabs. The preseason favorite in the division, the San Francisco 49ers, have struggled and now have to go to Lambeau Field to play the Green Bay Packers. 

The Philadelphia Eagles visit the Los Angeles Rams on Sunday Night Football, and the action stays in Inglewood for the Ravens-Chargers Harbaugh Bowl on Monday. Jim and John will oppose each other for the first time since Super Bowl XLVIII, with Baltimore looking to gain ground after the Steelers' upset loss on Thursday and L.A. suddenly looking quite dangerous. 

Before you make your Week 12 NFL prop picks or bets, be sure you check out the top NFL picks and predictions from NFL props expert Alex Selesnick.

Selesnick (aka PropStarz) specializes in NFL, MLB and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling. 

The expert has been crushing his picks in all sports and entered the 2024 NFL season on a 461-350 streak, returning 62.6 units. The expert has went 207-142 on MLB prop plays for SportsLine this season and was 338-246 on NBA props last season.

After analyzing every matchup and hundreds of Week 12 NFL player props, including one on Broncos QB Bo Nix!

PropStarz has locked in several more of his favorite Week 12 NFL prop picks, and they include a big effort from another quarterback! You NEED to see the expert's best bets and the players you need to back (or fade) before deciding on your NFL Week 12 prop picks

Which NFL prop bets should you target in NFL Week 12? And which QB is a MUST-BACK? ... Join SportsLine right now to see the top NFL prop picks you can make, all from the expert who entered the season on a 461-350 run!