The No. 15-seeded South Dakota State Jackrabbits (22-12) face the No. 2-seeded Iowa State Cyclones (27-7) on Thursday in a 2024 NCAA Tournament first-round matchup. Tipoff is set for 7:35 p.m. ET from CHI Health Center in Omaha, Neb. The Cyclones are 16-point favorites and the over/under for total points scored is 135.5 in the latest South Dakota State vs. Iowa State odds from SportsLine consensus. 

Before making any South Dakota State vs. Iowa State picks or NCAA Tournament predictions, you need to check out the college basketball predictions from the SportsLine Projection Model. (See up-to-date odds for every game this week on our college basketball odds page.)

The model simulates every Division I college basketball game 10,000 times. It enters the 2024 NCAA tournament on a 148-106 roll on all top-rated college basketball picks dating back to last season, returning more than $1,700 for $100 players. It also has a strong 29-19 (+810) record on top-rated spread picks this season. Anyone following it has seen huge returns.

For Thursday, the model has set its sights on South Dakota State vs. Iowa State. We can tell you the model is leaning Over on the point total, and it also says one side of the spread hits in well over 50% of simulations! You absolutely need to see the model before locking in any college basketball picks.

Who wins South Dakota State vs. Iowa State, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model that's 29-19 on top-ranked college basketball spread picks!