A pair of top seeds collide Friday as the South Carolina Gamecocks take on the Louisville Cardinals in a Final Four game of the 2022 Women's NCAA Tournament. South Carolina (33-2), the No. 1 seed in the Greensboro Region, advanced to the Final Four for the second straight year by rolling past Creighton 80-50. Seeded first in the Wichita Region, Louisville (29-4) defeated Michigan 62-50 to reach the Final Four for the fourth time in school history.

Tipoff at the Target Center in Minneapolis is set for 7 p.m. ET. The Gamecocks are eight-point favorites in the latest South Carolina vs. Louisville 2022 Women's NCAA Tournament odds from Caesars Sportsbook, while the over-under for total points scored is 119.

Before you lock in any Women's NCAA Tournament bets or women's college basketball predictions, you NEED to see what women's college basketball experts Calvin Wetzel and Aaron Barzilai are saying.

Barzilai is a Ph.D. from Stanford who served as Director of Basketball Analytics for the Philadelphia 76ers. Five years ago, he founded HerHoopStats.com -- a groundbreaking website that unlocks insights about the women's game. Wetzel, the site's lead betting writer, incorporates his mathematical background and strong knowledge of women's NCAA hoops to turn the site's prediction model into picks.

Barzilai and Wetzel got off to a fast start with SportsLine as they went 13-7 on their first 20 picks. Currently, they are 590-430 overall (+127.40 units, +13.6 percent) in the 2021-22 women's college basketball season. Anyone who has followed them has seen HUGE returns.

Barzilai and Wetzel know South Carolina is seeking its second national title and looking to erase the memory of last year's one-point loss to Stanford in the Final Four from its mind. The Gamecocks are led by junior forward Aliyah Boston, who is first on the Gamecocks with averages of 16.8 points and 12.2 rebounds. Boston scored a team-high 19 points against Creighton while senior forward Victaria Saxton registered her first double-double of the season with 11 points and 11 boards.

The experts also know Louisville suffered back-to-back Elite Eight losses before getting past the Wolverines on Monday. Sophomore guard Hailey Van Lith, who leads the Cardinals with an average of 14.5 points, scored a team-high 22 in the victory while senior guard Chelsie Hall went 3-for-4 from beyond the arc en route to 15 points. Senior forward Emily Engstler, who is Louisville's leader in rebounding (9.4), scored only five points but recorded a season-best 16 boards, six steals and four assists.

Wetzel and Barzilai have taken a close look at the South Carolina vs. Louisville matchup from every angle and revealed their picks, including a CONFIDENT spread prediction and a strong lean on the total. You ABSOLUTELY need to see their breakdown before locking in any women's college basketball picks of your own.

Who wins South Carolina vs. Louisville in Friday's Final Four matchup? And which wager is a MUST-BACK for the 2022 Women's NCAA Tournament? ... Join SportsLine right now to find out which side of the Louisville vs. South Carolina spread you should be all over Friday, all from the experts who are 590-430 on their women's college basketball picks!