Serena Williams continues her quest for a record-tying 24th Grand Slam championship when she takes on Anett Kontaveit in the second round of the 2022 U.S. Open at Flushing Meadows on Wednesday at 7 p.m. ET. The 40-year-old Williams, who is expected to retire after the tournament, has won 23 major titles - the most in the Open Era - and is one behind Margaret Court on the all-time list. Williams has won the U.S. Open on six occasions - most recently in 2014, the last of a three-year run.

Kontaveit is a -250 favorite (risk $250 to win $100) in the latest Kontaveit vs. Williams odds from Caesars Sportsbook, while Williams is a +190 underdog. The over/under for total games in the match is 20.5, with Kontaveit favored by 3.5 games. Before you make any Williams vs. Kontaveit picks or 2022 U.S. Open predictions, you need to see what tennis expert Jose Onorato has to say.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bet. He studies current form, players' tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach helped Onorato go 69-46 -- up 54.98 units -- from January through July.

Now, Onorato has scrutinized the Williams vs. Kontaveit matchup in the second round of the 2022 U.S. Open and released his coveted pick. You ABSOLUTELY need to see what it is before locking in any 2022 U.S. Open picks of your own!

Who wins the Kontaveit vs. Williams match in the second round of the 2022 U.S. Open? ... Join SportsLine right now to see Jose Onorato's prediction and analysis for the 2022 U.S. Open women's match, all from the tennis expert who went 69-46 from January through July!