The United States squad has the clear advantage this week when it faces the International team at the 2022 Presidents Cup at Quail Hollow Club in Charlotte, N.C. The Americans will be led by reigning Masters winner and world No. 1 Scottie Scheffler and 2020 FedEx Cup champ Patrick Cantlay. The International squad features 2021 Masters champion Hideki Matsuyama and former Tour Rookie of the Year Sungjae Im. The LIV Golf defections of Cameron Smith and Joaquin Niemann left an already inferior International squad without two of its top players.

Team USA is the -750 favorite in the latest 2022 President Cup odds from Caesars Sportsbook, with the Internationals a +700 underdog and a tie priced at +1800. Before you lock in any 2022 Presidents Cup picks, be sure you check out the predictions and best bets from golf insider Patrick McDonald.

After spending time at FanSided and NBC Sports EDGE, McDonald joined CBS Sports as a golf writer in the spring of 2022. Now covering the sport from a broader perspective, McDonald still likes to dip his toes into the betting pools on a weekly basis on the PGA Tour. 

He takes a measured approach to his outright selections and finished the 2021-22 season up 42 units on those plays in 2022, having hit Cameron Smith (22-1) at the Tournament of Champions, Hudson Swafford (250-1) at The American Express, Joaquin Niemann (70-1) at the Genesis Invitational and Justin Thomas (66-1) live at the PGA Championship.

Now, McDonald has studied the 2022 Presidents Cup field and locked in his best bets, top sleepers and favorites to avoid. SHOCKINGLY, McDonald is fading PGA Tour Player of the Year Scheffler in the top scorers market! The 26-year-old was dominant for much of the season, but he collapsed at the Tour Championship, and his recent putting woes have made him beatable. If he falters early, McDonald thinks he could even spend some time on the bench! 

Instead, McDonald is targeting a player who is priced at more than 20-1 to score the most points this week at Quail Hollow! This golfer has the match-play experience and has had success on this course, and his short game and putter have been rounding into solid form. You ABSOLUTELY need to see who it is before locking in any Presidents Cup 2022 picks of your own!

So which 2022 Presidents Cup players should you target or avoid? And which player could you cash in on at more than 20-1 in the international matchup in Charlotte, N.C.? ... Join SportsLine right now to see Patrick McDonald's top picks for the 2022 Presidents Cup, all from the expert who finished the 2022 season up more than 42 units on outright plays, and find out!