Nick Chubb leads the league in rushing with 341 yards, and only Saquon Barkley and Cordarelle Patterson are also above 300 rushing yards. Stefon Diggs (344 yards) enters Week 4 with a slight lead over Jaylen Waddle (342) for the receiving yardage lead, with Waddle's Dolphins teammate Tyreek Hill (317) next. But which players will make the biggest impact in Week 4? Before you make any 2022 NFL prop picks for Week 4, be sure to see the top NFL picks and predictions from NFL props expert Alex Selesnick.

Selesnick (aka PropStarz) specializes in NFL, MLB and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling. 

The expert is 7-4 (+2.54 units) on NFL prop picks in this column through the first three weeks, after going an impressive 53-37 during the 2021 regular season. He also is 129-89 (+25.69 units) on MLB prop plays this year and up nearly 235 units on NBA props and futures plays over the past two-plus seasons.

After poring over scores of available NFL prop odds, PropStarz found four picks he loves for Week 4. One he is confident in is Giants running back Saquon Barkley Longest rush Over 16.5 yards (-115). Barkley is locked in to a healthy amount of attempts and has perhaps his best matchup of the season, PropStarz says.

PropStarz has locked down three other CONFIDENT prop bets, including a wide receiver who has already hit his Over once in this column this year. The expert also has two bonus long-shot leans players to lead the league in one yardage category for Week 4, including one that would pay a WHOPPING 30-1! You really NEED to see his best bets before deciding on your prop picks.

What NFL prop bets should you make for NFL Week 4? And which epic prop would pay 30-1? ... Join SportsLine right now to see the top NFL prop picks you can make, all from the expert who was up almost 62 units on NFL prop bets last season!