The Green Bay Packers will battle the San Francisco 49ers in their 2022 NFL preseason opener on Friday. The game will be a rematch of their 2021 NFC divisional round matchup won by San Francisco, 13-10. The Packers finished the regular season 13-4, while the 49ers were 10-7.

Kickoff at Levi's Stadium in Santa Clara, Calif., is set for 8:30 p.m. ET. San Francisco is a 2.5-point favorite in the latest Packers vs. 49ers odds from Caesars Sportsbook, while the Over-Under for total points scored is 33. 

Before you make any Packers vs. 49ers picks of your own, you NEED to hear what NFL expert R.J. White has to say.

Over the past seven years White, a CBS Sports fantasy and gambling editor, has gone 329-250-21 (56.8 percent) in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. He also is SportsLine's No. 1 NFL expert, going 445-378-24 on his against-the-spread NFL picks from 2017-21, returning $2,542 to $100 players. 

In addition, White has gone 50-17-1 on his last 68 picks involving the Packers, returning $3,077. Anyone who has followed him is WAY UP!

Now, White has locked in another confident pick against the spread pick for Packers vs. 49ers. We can tell you he's leaning Under the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins 49ers vs. Packers? And what critical x-factor makes one side of the spread hit hard? Join SportsLine now to find out, all from SportsLine's top NFL expert who is a sizzling 50-17 on Green Bay picks.