Jay Wright and the Villanova Wildcats face Bill Self and the Kansas Jayhawks in a Final Four matchup in New Orleans at 6:09 p.m. ET on Saturday. Kansas is favored by four points at Caesars Sportsbook, while the Over-Under is set at 134 (see up-to-date odds for every game this week on our college basketball odds page). Villanova guard Justin Moore (Achilles) is out for this one. 

Before making any Villanova vs. Kansas picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Villanova has been lights-out on defense in recent days. The Wildcats held Michigan and Houston to just 99 points combined, and no team has scored more than 61 points against Villanova in a 2022 NCAA Tournament game. Villanova is a top-20 team in the country in defensive efficiency, and the Wildcats are allowing only 30.1 percent shooting from 3-point range. the Wildcats are also in the top 50 of the nation in free-throw rate allowed, and Villanova forces a turnover on almost 19 percent of defensive possessions.

The model also knows Kansas is fantastic on offense. The Jayhawks are led by Ochai Agbaji, a projected first-round pick who is averaging 18.9 points and 5.2 rebounds per game. Kansas ranks in the top 10 of the country in offensive efficiency, making nearly 54 percent of 2-point attempts and more than 35 percent of 3-point attempts. The Jayhawks are also strong in ball security and offensive rebounding, creating extra opportunities and Kansas assists on almost 54 percent of its field goals.

Now, it has set its sights on Villanova vs. Kansas. We can tell you the model is leaning over the total, and it also says one side of the spread hits in 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Saturday's Villanova vs. Kansas matchup in the Final Four? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to find out which side of the Villanova vs. Kansas spread you should be all over Saturday, all from the model on a roll on college basketball picks!