The 2022 NCAA Tournament has seen its fair share of upsets, and teams like Arizona, Gonzaga and Kansas will look to avoid a letdown when the Sweet 16 gets underway on Thursday. The North Carolina Tar Heels knocked off the defending champion Baylor Bears and will now square off against UCLA in the Sweet 16. The Bruins are two-point favorites at Caesars Sportsbook in the latest 2022 NCAA Tournament odds. Other top 2022 March Madness Sweet 16 matchups include Duke vs. Texas Tech (-1), Michigan vs. Villanova (-5) and Houston vs. Arizona (-2). 

Before making any Sweet 16 picks for the 2022 NCAA Tournament, you NEED to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, the model has evaluated the latest March Madness odds, simulated every Sweet 16 matchup, and the results are in.

We can tell you one of the model's strongest Sweet 16 picks is that the Gonzaga Bulldogs (-8.5) cover the spread against the Arkansas Razorbacks in well over 70 percent of simulations. Another one of its March Madness predictions: The Miami Hurricanes (-2.5) cover against the Iowa State Cyclones 60 percent of the time. The model also says you should back the Over (133.5) in that Sweet 16 showdown.

The model has also made the call on who will win and cover every other Sweet 16 matchup and has identified a No. 1 seed that goes down HARD! It also says an underdog wins outright well over 60 percent of the time! You ABSOLUTELY need to see its March Madness picks for every single game before locking in your own.

So which teams should you back in the Sweet 16? And which underdog wins well over 60% of the time? ... Join SportsLine right now to find out who wins and covers every single Sweet 16 matchup, all from the model on a roll on college basketball picks!