The 2022 French Open features a headline-grabbing matchup on Friday. Rafael Nadal, in search of a 14th title at Roland Garros, takes on Alexander Zverev in a semifinal match with a berth in the final on the line. Nadal is a -330 favorite (risk $330 to win $100) in the latest Nadal vs. Zverev odds from Caesars Sportsbook, while Zverev is a +250 underdog. The over/under for total games is 36.5. The match will not begin before 8:45 a.m. ET.

Before you lock in any 2022 French Open men's semifinals picks or Nadal vs. Zverev props, you MUST see whom Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Djokovic or Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls.

Now, Calvert has released best bets for the Nadal vs. Zverev. We can tell you that he has a full breakdown, headlined by a plus-money bet that has to be seen. You ABSOLUTELY need to check out all of Calvert's picks and analysis of the 2022 French Open before you bet.

So who wins Nadal vs. Zverev? And which plus-money wager could lead to a HUGE return? ... Join SportsLine right now to see Sean Calvert's top 2022 French Open quarterfinal picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1!