No. 7 seed Andrey Rublev faces No. 4 seed Daniil Medvedev in the 2021 Australian Open quarterfinals. William Hill Sportsbook lists Medvedev is a -275 favorite (risk $275 to win $100), with Rublev getting +210 as the underdog.

There are several angles to bet the match, however, including an Over-Under on the total games played and a first-set tie-break that is listed at +175. Before you lock in any 2021 Australian Open men's quarterfinals picks, you MUST see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is WAY UP!

Now, Calvert has released best bets for the Medvedev vs. Rublev, including a look at the opening set. You ABSOLUTELY need to see all of Calvert's picks and analysis of the 2021 Australian Open before you bet.

So who wins Medvedev vs. Rublev? And which pick could lead to a HUGE return? ... Join SportsLine right now to see Sean Calvert's top 2021 Australian Open quarterfinal picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1! -- Use promo code TENNIS to get your first month of SportsLine for a buck!