Second-seeded Rafael Nadal faces young Greek star and No. 5 seed Stefanos Tsitsipas in the 2021 Australian Open men's quarterfinals. Nadal is a -225 favorite (risk $225 to win $100), while Tsitsipas is a +275 underdog in the latest 2021 Australian Open odds from William Hill Sportsbook.

Before you lock in any 2021 Australian Open men's quarterfinals picks or props, you MUST see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1, among many stunning calls. Anyone following his picks is WAY UP!

Now, Calvert has released best bets for the Nadal vs. Tsitsipas, including a STRONG play on the outright winner. You ABSOLUTELY need to see all of Calvert's picks and analysis of the 2021 Australian Open before you bet.

So who wins Nadal vs. Tsitsipas? And which pick could lead to a HUGE return? ... Join SportsLine right now to see Sean Calvert's top 2021 Australian Open quarterfinal picks, all from the acclaimed expert who called Stan Wawrinka winning the 2014 Australian Open at 60-1! -- Use promo code TENNIS to get your first month of SportsLine for a buck!