White Sox vs. Guardians line, odds, start time, pick, best bets for April 8 matchup from proven model
SportsLine's projection model, which is on a profitable 34-19 run, has locked in its MLB picks for the Cleveland Guardians vs. Chicago White Sox at Progressive Field on Tuesday
The Chicago White Sox and Cleveland Guardians are set to begin a three-game series in Cleveland Tuesday, with the Guardians off to a 3-5 start and the White Sox at 2-7 through nine games. Cleveland is coming off a 6-2 loss to the Angels Sunday, losing two of three games in the series. Chicago enters off a 4-3 loss to the Tigers Sunday in a three-game sweep.
First pitch from Progressive Field in Cleveland, Ohio., is set for 4:10 p.m. ET. Cleveland is a -196 favorite on the money line (risk $196 to win $100) in the latest White Sox vs. Guardians odds, while Chicago is a +163 underdog. The over/under is 7.5 in the latest MLB odds via SportsLine consensus.
Before making any Guardians vs. White Sox picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 3 of the 2025 MLB season on a 34-19 roll on top-rated run-line picks (+629). Anybody following could have seen strong returns!
The model has simulated Guardians vs. White Sox 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line is the better value!
Who wins White Sox vs. Guardians, and which side of the money line is the better value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 34-19 roll on top-rated MLB picks!