The first-ever 12-team College Football Playoff has arrived, and Saturday, Dec. 21 contains the bulk of the quarterfinal action. It starts off with No. 6 Penn State favored by 9 points over No. 11 SMU, per the latest college football odds. Then, No. 5 Texas is giving 11 points to No. 12 Clemson, and finally, you can make CFP bets on No. 8 Ohio State facing No. 9 Tennessee (+7.5). All of the better seeded teams are hosting the matchups for this portion of the College Football Playoff schedule. Which sides should get your CFP predictions and college football best bets?

SportsLine's college football experts and advanced computer model have analyzed the entire December 21 CFP schedule and revealed the top college football picks, college football betting trends, college football best bets, and more. If you're not already a subscriber, join SportsLine here to get everything you need to crush your college football picks!