Rockets vs. Lakers prediction, odds, line, spread, start time: 2025 NBA picks, April 11 best bets from proven computer simulation model
SportsLine's model has locked in its NBA best bets and predictions for Friday's Los Angeles Lakers vs. Houston Rockets matchup

The Houston Rockets hit the road to take on the Los Angeles Lakers in a game with significant Western Conference playoff implications on Friday. Los Angeles is 49-31 overall and 30-10 at home, while Houston is 52-28 overall and 23-16 at home. The Rockets have clinched the No. 2 seed in the Western Conference, while the Lakers are looking to stay in possession of third place. Los Angeles is coming off a 112-97 win over the Dallas Mavericks on Wednesday. Houston is aiming to bounce back from a 134-117 loss to the Los Angeles Clippers on April 9. Dillon Brooks (rest), Jabari Smith Jr. (groin), Fred VanVleet (ankle), and Alperen Sengun (personal) are all out for the Rockets.
Tipoff from Crypto.com Arena in Los Angeles is set for 10:30 p.m. ET. Los Angeles is a 12.5-point favorite in the latest Rockets vs. Lakers odds from SportsLine consensus, and the over/under is 227.5 points. Los Angeles is listed at -763 (risk $763 to win $100), while Houston is at +535 on the moneyline. Before making any Rockets vs. Lakers picks, you'll want to check out the NBA predictions and betting advice from the SportsLine Projection Model.
The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the final week of the 2024-25 NBA regular season on a sizzling 155-115 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 21-10 (68%) on top-rated spread picks this season. Anyone following could have seen HUGE returns!
The model has simulated Rockets vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it also says one side of the spread hits in well over 60% of computer simulations!
Who wins Rockets vs. Lakers, and which side of the spread hits well over 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 155-115 roll on top-rated NBA picks!