Dodgers vs. Cubs odds, line, start time, picks, best bets for 2025 Tokyo Series matchup from proven model
SportsLine's projection model, which enters the 2025 MLB season on a 32-17 roll on top-rated run-line picks, has locked in its MLB picks for the Los Angeles Dodgers vs. Chicago Cubs in the 2025 Tokyo Series matchup on Wednesday

The Los Angeles Dodgers (1-0) and the Chicago Cubs (0-1) close out the 2025 Toyko Series on Wednesday. In Game 1 of this series, Los Angeles took down Chicago 4-1. Roki Sasaki is set to make his debut for Los Angeles in Game 2. Meanwhile, Justin Steele is on the hill for Chicago.
First pitch is scheduled for 6:10 a.m. ET at the Tokyo Dome in Tokyo, Japan. The Dodgers are the -151 money-line favorites (bet $151 to win $100) in the latest Dodgers vs. Cubs odds, while the Cubs are +127 underdogs (bet $100 to win $127). The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus.
Before you make any Dodgers vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 32-17 roll on top-rated run-line picks (+699) that dates back to 2023. Anybody following could have seen STRONG returns!
The model has simulated Dodgers vs. Cubs 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!
Who wins Dodgers vs. Cubs, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 32-17 roll on top-rated MLB run-line picks!