The San Francisco 49ers will take on the Minnesota Vikings at 4:25 p.m. ET on Sunday at Levi's Stadium. The 49ers are 5-5 overall and 1-4 at home, while Minnesota is 5-5 overall and 2-3 on the road. 

San Francisco is favored by three points in the latest 49ers vs. Vikings odds from Caesars Sportsbook, and the over-under is set at 49. Before you make any Vikings vs. 49ers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated 49ers vs. Vikings 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins 49ers vs. Vikings? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!