NFL schedule 2021: Week 5 picks, odds, predictions, best bets, spreads, DFS plays, TV coverage for all games

Week 5 NFL picks, best bets, point spreads, expert betting advice and TV coverage for all 16 games

SportsLine Staff

The first month of the 2021 NFL season is in the books, and as expected the action lived up to the hype. After four weeks, only one team remains undefeated -- the Arizona Cardinals; several surprising teams have emerged as top Super Bowl 56 contenders -- the Dallas Cowboys, Cleveland Browns, Los Angeles Chargers, and the Cardinals; and the race for the No. 1 overall pick in the 2022 NFL Draft is officially on, with the Detroit Lions and Jacksonville Jaguars leading the way.

Against the spread favorites 8-8 in Week 4, marking the first time ATS underdogs haven't prevailed in the weekly standings in 2021. Will Week 5 be the week the favorites finally come out ahead? Or will the underdogs continue to cover spreads at an eye-opening rate? Only time will tell.

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The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP front-runner Kyler Murray; and a Sunday Night Football matchup between the Chiefs and Bills, which will serve as a rematch of last year's AFC Championship Game.

Here is a full rundown of the NFL Week 5 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups.

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Los Angeles Rams vs. Seattle Seahawks

Rams vs. Seahawks date and time: Thursday, October 7 at 8:20 p.m. ET
Rams vs. Seahawks spread: Rams -2
Rams vs. Seahawks over-under: 54.5
Rams vs. Seahawks moneyline: Seahawks +115, Rams -135
Rams vs. Seahawks TV Coverage: NFL Network

Expert Seahawks vs. Rams picks HERE. Expert Rams vs. Seahawks DFS lineup advice HERE.

New York Jets vs. Atlanta Falcons (London)

Falcons vs. Jets date and time: Sunday, October 10 at 9:30 a.m. ET from Tottenham Hotspur Stadium in London
Falcons vs. Jets spread: Falcons -3
Falcons vs. Jets over-under: 46
Falcons vs. Jets moneyline: Jets +140, Falcons -160
Falcons vs. Jets TV coverage: NFL Network

Green Bay Packers vs. Cincinnati Bengals

Packers vs. Bengals date and time: Sunday, October 10 at 1 p.m. ET
Packers vs. Bengals spread: Packers -3
Packers vs. Bengals over-under: 50.5
Packers vs. Bengals moneyline: Packers -160, Bengals +140
Packers vs. Bengals TV coverage: Fox

Detroit Lions vs. Minnesota Vikings

Lions vs. Vikings date and time: Sunday, October 10 at 1 p.m. ET
Lions vs. Vikings spread: Vikings -7.5
Lions vs. Vikings over-under: 49
Lions vs. Vikings moneyline: Vikings -350, Lions +280
Lions vs. Vikings TV coverage: Fox

Denver Broncos vs. Pittsburgh Steelers

Broncos vs. Steelers date and time: Sunday, October 10 at 1 p.m. ET
Broncos vs. Steelers spread: Steelers -1
Broncos vs. Steelers over-under: 40
Broncos vs. Steelers moneyline: Broncos -105, Steelers -115
Broncos vs. Steelers TV coverage: Fox

Expert Steelers vs. Broncos player prop bet picks HERE.

Tampa Bay Buccaneers vs. Miami Dolphins

Buccaneers vs. Dolphins date and time: Sunday, October 10 at 1 p.m. ET
Buccaneers vs. Dolphins spread: Buccaneers -10
Buccaneers vs. Dolphins over-under: 48
Buccaneers vs. Dolphins moneyline: Dolphins +360, Buccaneers -475
Buccaneers vs. Dolphins TV coverage: CBS

New Orleans Saints vs. Washington Football Team

Saints vs. Washington date and time: Sunday, October 10 at 1 p.m. ET
Saints vs. Washington spread: Saints -1.5
Saints vs. Washington over-under: 44.5
Saints vs. Washington moneyline: Saints -130, Washington +110
Saints vs. Washington TV coverage: CBS

Expert Saints vs. Washington player prop bet picks HERE.

Philadelphia Eagles vs. Carolina Panthers

Eagles vs. Panthers date and time: Sunday, October 10 at 1 p.m. ET
Eagles vs. Panthers spread: Panthers -4
Eagles vs. Panthers over-under: 45
Eagles vs. Panthers moneyline: Eagles +160 Panthers -190
Eagles vs. Panthers TV coverage: Fox

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Tennessee Titans vs. Jacksonville Jaguars

Titans vs. Jaguars date and time: Sunday, October 10 at 1 p.m. ET
Titans vs. Jaguars spread: Titans -4
Titans vs. Jaguars over-under: 48.5
Titans vs. Jaguars moneyline: Titans -200, Jaguars +170
Titans vs. Jaguars TV coverage: CBS

Expert Jaguars vs. Titans picks HERE.

New England Patriots vs. Houston Texans

Patriots vs. Texans date and time: Sunday, October 10 at 1 p.m. ET
Patriots vs. Texans spread: Patriots -9
Patriots vs. Texans over-under: 39.5
Patriots vs. Texans moneyline: Texans +330, Patriots -430
Patriots vs. Texans TV coverage: CBS

Chicago Bears vs. Las Vegas Raiders

Bears vs. Raiders date and time: Sunday, October 10 at 4:05 p.m. ET
Bears vs. Raiders spread: Raiders -5.5
Bears vs. Raiders over-under: 44.5
Bears vs. Raiders moneyline: Bears +200, Raiders -240
Bears vs. Raiders TV coverage: CBS

Cleveland Browns vs. Los Angeles Chargers

Browns vs. Chargers date and time: Sunday, October 10 at 4:05 p.m. ET
Browns vs. Chargers spread: Chargers -1.5
Browns vs. Chargers over-under: 48.5
Browns vs. Chargers moneyline: Browns +105, Chargers -125
Browns vs. Chargers TV coverage: CBS

Expert Chargers vs. Browns picks HERE.

Arizona Cardinals vs. San Francisco 49ers

Cardinals vs. 49ers date and time: Sunday, October 10 at 4:25 p.m. ET
Cardinals vs. 49ers spread: Cardinals -5.5
Cardinals vs. 49ers over-under: 50
Cardinals vs. 49ers moneyline: Cardinals -250, 49ers +205
Cardinals vs. 49ers TV coverage: Fox

Expert 49ers vs. Cardinals picks HERE.

New York Giants vs. Dallas Cowboys

Giants vs. Cowboys date and time: Sunday, October 10 at 4:25 p.m. ET
Giants vs. Cowboys spread: Cowboys -7
Giants vs. Cowboys over-under: 52
Giants vs. Cowboys moneyline: Giants +260, Cowboys -330
Giants vs. Cowboys TV coverage: Fox

Expert Cowboys vs. Giants picks HERE.

Buffalo Bills vs. Kansas City Chiefs

Bills vs. Chiefs date and time: Sunday, October 10 at 8:20 p.m. ET
Bills vs. Chiefs spread: Chiefs -2.5
Bills vs. Chiefs over-under: 56.5
Bills vs. Chiefs moneyline: Bills +130, Chiefs -150
Bills vs. Chiefs TV coverage: NBC

Expert Chiefs vs. Bills picks HERE.

Indianapolis Colts vs. Baltimore Ravens

Colts vs. Ravens date and time: Monday, October 11 at 8:15 p.m. ET
Colts vs. Ravens spread: Ravens -7
Colts vs. Ravens over-under: 46
Colts vs. Ravens moneyline: Colts +260, Ravens -330
Colts vs. Ravens TV coverage: ESPN