NFL schedule 2021: Week 4 picks, odds, predictions, best bets, spreads, lines, TV coverage for all 16 games

Week 4 NFL picks, best bets, point spreads and TV coverage for all 16 games including the return of Tom Brady to New England

SportsLine Staff

The first three weeks of the 2021 NFL season have lived up to the lofty expectations that have become the norm for the National Football League. In Week 3, Justin Tucker nailed a NFL record 66-yard, walk off field goal to give the Ravens a win over the Lions; Justin Herbert out-dueled Patrick Mahomes, leading the Chargers to a 30-24 win over the Chiefs; Matthew Stafford and the Rams cemented their place among the top Super Bowl 56 contenders with a dominating 34-24 win over Tom Brady and the Buccaneers; and Aaron Rodgers delivered a clutch fourth quarter performance, guiding the Packers to a 30-28 win over the 49ers.

Against the spread underdogs 9-7 in Week 3, continuing the trend of betting favorites falling short. Will that trend continue in Week 4? Or will this week tilt more towards the betting favorites?

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The NFL Week 4 schedule features a full slate of games with several intriguing matchups including Cowboys vs. Panthers in a matchup between two of the top teams in the NFC thus far; the Rams vs. Cardinals, in a matchup between two undefeated teams with Super Bowl aspirations and MVP candidates at quarterback; Seahawks vs. 49ers in a matchup between two bitter NFC West rivals; and Buccaneers vs. Patriots on Sunday Night Football, where fans Tom Brady will make his return to Gillette Stadium where he will likely break the NFL career passing yards record early in the first half.

Here is a full rundown of the NFL Week 4 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups.

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Jacksonville Jaguars vs. Cincinnati Bengals

Bengals vs. Jaguars date and time: Thursday, September 30 at 8:20 p.m. ET
Bengals vs. Jaguars spread: Bengals -7.5
Bengals vs. Jaguars over-under: 46
Bengals vs. Jaguars moneyline: Jaguars +280, Bengals -350
Bengals vs. Jaguars TV Coverage: NFL Network

Expert Bengals vs. Jaguars picks HERE.

Washington Football Team vs. Atlanta Falcons

Falcons vs. Washington date and time: Sunday, October 3 at 1 p.m. ET
Falcons vs. Washington spread: Washington -1.5
Falcons vs. Washington over-under: 48
Falcons vs. Washington moneyline: Washington -120, Falcons +100
Falcons vs. Washington TV coverage: Fox

Houston Texans vs. Buffalo Bills

Texans vs. Bills date and time: Sunday, October 3 at 1 p.m. ET
Texans vs. Bills spread: Bills -16.5
Texans vs. Bills over-under: 47
Texans vs. Bills moneyline: Bills -1600, Texans +850
Texans vs. Bills TV coverage: CBS

Detroit Lions vs. Chicago Bears

Lions vs. Bears date and time: Sunday, September 19 at 1 p.m. ET
Lions vs. Bears spread: Bears -3
Lions vs. Bears over-under: 42.5
Lions vs. Bears moneyline: Bears -150, Lions +130
Lions vs. Bears TV coverage: Fox

Carolina Panthers vs. Dallas Cowboys

Panthers vs. Cowboys date and time: Sunday, October 3 at 1 p.m. ET
Panthers vs. Cowboys spread: Cowboys -5
Panthers vs. Cowboys over-under: 50.5
Panthers vs. Cowboys moneyline: Panthers +180, Cowboys -220
Panthers vs. Cowboys TV coverage: Fox

Expert Cowboys vs. Panthers prop bet picks HERE.

Indianapolis Colts vs. Miami Dolphins

Colts vs. Dolphins date and time: Sunday, October 3 at 1 p.m. ET
Colts vs. Dolphins spread: Dolphins -1.5
Colts vs. Dolphins over-under: 43
Colts vs. Dolphins moneyline: Dolphins -130, Colts +110
Colts vs. Dolphins TV coverage: CBS

Cleveland Browns vs. Minnesota Vikings

Browns vs. Vikings date and time: Sunday, October 3 at 1 p.m. ET
Browns vs. Vikings spread: Browns -2
Browns vs. Vikings over-under: 51.5
Browns vs. Vikings moneyline: Browns -130, Vikings +110
Browns vs. Vikings TV coverage: CBS

New York Giants vs. New Orleans Saints

Giants vs. Saints date and time: Sunday, October 3 at 1 p.m. ET
Giants vs. Saints spread: Saints -8
Giants vs. Saints over-under: 43
Giants vs. Saints moneyline: Saints -400, Giants +310
Giants vs. Saints TV coverage: Fox

Tennessee Titans vs. New York Jets

Titans vs. Jets date and time: Sunday, October 3 at 1 p.m. ET
Titans vs. Jets spread: Titans -7.5
Titans vs. Jets over-under: 46
Titans vs. Jets moneyline: Titans -380, Jets +300
Titans vs. Jets TV coverage: CBS

Expert Jets vs. Titans picks HERE.

Kansas City Chiefs vs. Philadelphia Eagles

Chiefs vs. Eagles date and time: Sunday, October 3 at 1 p.m. ET
Chiefs vs. Eagles spread: Chiefs -7
Chiefs vs. Eagles over-under: 54.5
Chiefs vs. Eagles moneyline: Eagles +270, Chiefs -340
Chiefs vs. Eagles TV coverage: CBS

Expert Eagles vs. Chiefs prop bet picks HERE.

Arizona Cardinals vs. Los Angeles Rams

Rams vs. Cardinals date and time: Sunday, September 19 at 4:05 p.m. ET
Rams vs. Cardinals spread: Rams -4.5
Rams vs. Cardinals over-under: 54.5
Rams vs. Cardinals moneyline: Cardinals +190, Rams -230
Rams vs. Cardinals TV coverage: Fox

Seattle Seahawks vs. San Francisco 49ers

Seahawks vs. 49ers date and time: Sunday, October 3 at 4:25 p.m. ET
Seahawks vs. 49ers spread: 49ers -2.5
Seahawks vs. 49ers over-under: 52
Seahawks vs. 49ers moneyline: Seahawks +140, 49ers -160
Seahawks vs. 49ers TV coverage: Fox

Expert 49ers vs. Seahawks picks HERE.

Baltimore Ravens vs. Denver Broncos

Broncos vs. Ravens date and time: Sunday, October 3 at 4:25 p.m. ET
Broncos vs. Ravens spread: Broncos -1
Broncos vs. Ravens over-under: 44
Broncos vs. Ravens moneyline: Ravens -105, Broncos -115
Broncos vs. Ravens TV coverage: CBS

Expert Ravens vs. Broncos prop bet picks HERE.

Pittsburgh Steelers vs. Green Bay Packers

Steelers vs. Packers date and time: Sunday, October 3 at 4:25 p.m. ET
Steelers vs. Packers spread: Packers -6.5
Steelers vs. Packers over-under: 45.5
Steelers vs. Packers moneyline: Packers -320, Steelers +250
Steelers vs. Packers TV coverage: Fox

Tampa Bay Buccaneers vs. New England Patriots

Buccaneers vs. Patriots date and time: Sunday, October 3 at 8:20 p.m. ET
Buccaneers vs. Patriots spread: Buccaneers -6.5
Buccaneers vs. Patriots over-under: 49
Buccaneers vs. Patriots moneyline: Patriots +240, Buccaneers -300
Buccaneers vs. Patriots TV coverage: NBC

Las Vegas Raiders vs. Los Angeles Chargers

Lions vs. Packers date and time: Monday, October 4 at 8:15 p.m. ET
Lions vs. Packers spread: Chargers -3.5
Lions vs. Packers over-under: 52.5
Lions vs. Packers moneyline: Chargers -190, Raiders +160
Lions vs. Packers TV coverage: ESPN