| Date | Player | Pos. | Transaction |
| 5/17 | Hector Luna | 3B | Purchased From Minors |
| 5/17 | David Purcey | P | Sent to Minors |
| 5/16 | Jorge Velandia | SS | Designated for Assignment |
| 5/16 | David Purcey | P | Called Up from Minors |
| 5/15 | Jorge Velandia | SS | Sent to Minors |
| 5/10 | Armando Benitez | P | Purchased From Minors |
| 5/10 | Vernon Wells | CF | Placed on 15-Day DL, (Fractured left wrist) |
| 5/10 | Joe Inglett | 3B | Called Up from Minors |
| 5/10 | Jeremy Accardo | P | Placed on 15-Day DL, (Right forearm tightness) |
| 5/9 | Joe Inglett | 3B | Sent to Minors |
| 5/9 | Kevin Mench | LF | Purchased From Minors |
| 5/9 | Kevin Mench | LF | Traded From, Texas (for cash considerations) |
| 5/9 | Brad Wilkerson | RF | Signed as Free Agent, ( 2008) |
| 5/9 | Gustavo Chacin | P | Designated for Assignment |
| 5/8 | John McDonald | SS | Placed on 15-Day DL, (Sprained right ankle) |
| 5/8 | Joe Inglett | 3B | Called Up from Minors |
| 5/8 | David Eckstein | SS | Placed on 15-Day DL, (Strained right hip flexor) |
| 5/7 | Adam Lind | LF | Sent to Minors |
| 5/7 | Jorge Velandia | SS | Purchased From Minors |
| 4/26 | Joe Inglett | 3B | Sent to Minors |
| 4/26 | Adam Lind | LF | Called Up from Minors |
| 4/25 | Robinzon Diaz | C | Sent to Minors |
| 4/25 | Scott Rolen | 3B | Recalled From Minors, Rehab Assignment |
| 4/25 | Scott Rolen | 3B | Removed From 15-Day DL, (Broken right middle finger) |
| 4/20 | Scott Rolen | 3B | Sent to Minors, For Rehabilitation |
| 4/20 | Frank Thomas | DH | Released |
| 4/19 | David Purcey | P | Sent to Minors |
| 4/19 | Josh Banks | P | Designated for Assignment |
| 4/19 | Shawn Camp | P | Purchased From Minors |
| 4/17 | David Purcey | P | Called Up from Minors |
| 4/17 | Brian Wolfe | P | Placed on 15-Day DL, (Strained right triceps) |
| 4/16 | Randy Wells | P | Drafted Player Returned to Minors |
| 4/13 | Brandon League | P | Sent to Minors |
| 4/13 | B.J. Ryan | P | Recalled From Minors, Rehab Assignment |
| 4/13 | B.J. Ryan | P | Removed From 15-Day DL, (Left forearm & biceps soreness) |
| 4/12 | Buck Coats | RF | Sent to Minors |
| 4/12 | Joe Inglett | 2B | Called Up from Minors |
| 4/10 | Jesse Carlson | P | Purchased From Minors |
| 4/10 | Randy Wells | P | Designated for Assignment |
| 4/5 | B.J. Ryan | P | Sent to Minors, For Rehabilitation |
| 4/4 | Alex Rios | RF | Signed, ( 2009-2014; Opt 2015)(six-year extension) |
| 4/2 | Jorge Velandia | SS | Signed to a Minor League Contract |
| 3/30 | Bill Murphy | P | Sent to Minors |
| 3/30 | Scott Rolen | 3B | Placed on 15-Day DL, (Broken right middle finger) |
| 3/30 | B.J. Ryan | P | Placed on 15-Day DL, (Left forearm & biceps soreness) |
| 3/30 | Shannon Stewart | LF | Purchased From Minors |
| 3/25 | Sal Fasano | C | Released |
| 3/24 | Buck Coats | RF | Called Up from Minors |
| 3/23 | Reed Johnson | LF | Released |
| 3/17 | Bill Murphy | P | Acquired Off Waivers From, Arizona |
| 3/17 | Casey Janssen | P | Placed on 60-Day DL, (Torn right labrum - out for season) |
| 3/13 | Curtis Thigpen | 1B | Sent to Minors |
| 3/13 | Adam Lind | LF | Sent to Minors |
| 3/13 | Buck Coats | RF | Sent to Minors |
| 3/13 | Joe Inglett | 2B | Sent to Minors |
| 3/12 | Josh Banks | P | Sent to Minors |
| 3/12 | Gustavo Chacin | P | Sent to Minors |
| 3/11 | Armando Benitez | P | Signed to a Minor League Contract |
| 3/8 | Davis Romero | P | Sent to Minors |
| 2/24 | Shannon Stewart | LF | Signed to a Minor League Contract |
| 2/5 | Alex Rios | RF | Signed, ( 2008)(avoids arbitration) |
| 1/24 | Ray Olmedo | SS | Designated for Assignment |
| 1/24 | Rod Barajas | C | Signed as Free Agent, ( 2008; Opt 2009) |
| 1/17 | Gustavo Chacin | P | Signed, ( 2008)(avoids arbitration) |
| 1/17 | Scott Downs | P | Signed, ( 2008-2010)(three-year extension, avoids arbitration) |
| 1/17 | Jason Frasor | P | Signed, ( 2008)(avoids arbitration) |
| 1/17 | Marco Scutaro | 3B | Signed, ( 2008-2009)(two-year extension, avoids arbitration) |
| 1/17 | Brian Tallet | P | Signed, ( 2008)(avoids arbitration) |
| 1/14 | Scott Rolen | 3B | Traded From, St. Louis (for 3B Troy Glaus) |
| 1/7 | Shawn Camp | P | Signed to a Minor League Contract |
| 1/2 | Lance Carter | P | Signed to a Minor League Contract |
| 1/2 | Reed Johnson | LF | Signed, ( 2008)(avoids arbitration) |
| 1/2 | John Parrish | P | Signed to a Minor League Contract |
| 12/14 | Sal Fasano | C | Signed to a Minor League Contract |
| 12/13 | David Eckstein | SS | Signed as Free Agent, ( 2008) |
| 12/5 | Buck Coats | RF | Traded From, Cincinnati (for RHP Justin James) |
| More Transactions |
| Posted Sat May 17 13:02:52 EDT 2008 |
