| Date | Player | Pos. | Transaction |
| 7/10 | Randy Choate | P | Outrighted to Minors |
| 7/10 | Randy Choate | P | Removed From 15-Day DL, (Fractured left hand) |
| 7/10 | Randy Choate | P | Recalled From Minors, Rehab Assignment |
| 7/7 | Jeff Suppan | P | Placed on 15-Day DL, (Joint irritation, right elbow) |
| 7/7 | Zach Jackson | P | Called Up from Minors, - Not to Report |
| 7/7 | CC Sabathia | P | Traded From, Cleveland (for OF Matt LaPorta, five-player deal) |
| 6/30 | Eric Gagne | P | Recalled From Minors, Rehab Assignment |
| 6/30 | Mark DiFelice | P | Sent to Minors |
| 6/30 | Eric Gagne | P | Removed From 15-Day DL, (Right rotator cuff tendinitis) |
| 6/29 | Troy Cate | P | Signed to a Minor League Contract |
| 6/25 | Julian Tavarez | P | Refused Minor League Assignment - Free Agent |
| 6/24 | Eric Gagne | P | Sent to Minors, For Rehabilitation |
| 6/22 | Rickie Weeks | 2B | Removed From 15-Day DL, (Sprained left knee) |
| 6/22 | Hernan Iribarren | 2B | Sent to Minors |
| 6/20 | Tim Dillard | P | Sent to Minors |
| 6/20 | Mitch Stetter | P | Called Up from Minors |
| 6/19 | Julian Tavarez | P | Designated for Assignment |
| 6/19 | David Riske | P | Removed From 15-Day DL, (Hyperextended right elbow) |
| 6/19 | David Riske | P | Recalled From Minors, Rehab Assignment |
| 6/18 | Randy Choate | P | Sent to Minors, For Rehabilitation |
| 6/17 | David Riske | P | Sent to Minors, For Rehabilitation |
| 6/12 | Jeff Weaver | P | Released |
| 6/10 | Hernan Iribarren | 2B | Called Up from Minors |
| 6/9 | Rickie Weeks | 2B | Placed on 15-Day DL, (Sprained left knee) |
| 5/31 | Chris Woodward | 3B | Signed to a Minor League Contract |
| 5/27 | Julian Tavarez | P | Signed as Free Agent |
| 5/27 | Zach Jackson | P | Sent to Minors |
| 5/24 | Russell Branyan | 3B | Purchased From Minors |
| 5/24 | Tony Gwynn | CF | Sent to Minors |
| 5/23 | Tim Dillard | P | Called Up from Minors |
| 5/23 | Eric Gagne | P | Placed on 15-Day DL, (Right rotator cuff tendinitis) |
| 5/16 | Mitch Stetter | P | Sent to Minors |
| 5/16 | Zach Jackson | P | Called Up from Minors |
| 5/15 | David Riske | P | Placed on 15-Day DL, (Hyperextended right elbow) |
| 5/15 | Ryan Braun | LF | Signed, ( 2008-2015)(seven-year extension) |
| 5/9 | Derrick Turnbow | P | Outrighted to Minors |
| 5/3 | Dave Bush | P | Called Up from Minors |
| 5/3 | Yovani Gallardo | P | Placed on 15-Day DL, (Torn ACL, right knee) |
| 5/2 | Joe Dillon | LF | Called Up from Minors |
| 5/2 | Derrick Turnbow | P | Designated for Assignment |
| 4/29 | Mike Cameron | CF | Reinstated from Illegal Substance Suspension |
| 4/27 | Dave Bush | P | Sent to Minors |
| 4/23 | Tony Gwynn | CF | Removed From 15-Day DL, (Strained left hamstring) |
| 4/22 | Tony Gwynn | CF | Recalled From Minors, Rehab Assignment |
| 4/20 | Yovani Gallardo | P | Recalled From Minors, Rehab Assignment |
| 4/20 | Yovani Gallardo | P | Removed From 15-Day DL, (Torn lateral meniscus, left knee) |
| 4/20 | Joe Dillon | 2B | Sent to Minors |
| 4/17 | Tony Gwynn | CF | Sent to Minors, For Rehabilitation |
| 4/17 | Hernan Iribarren | 2B | Sent to Minors |
| 4/17 | Mitch Stetter | P | Called Up from Minors |
| 4/15 | Jeff Weaver | P | Signed to a Minor League Contract |
| 4/13 | Yovani Gallardo | P | Sent to Minors, For Rehabilitation |
| 4/9 | Yovani Gallardo | P | Recalled From Minors, Rehab Assignment |
| 4/9 | Tony Gwynn | CF | Placed on 15-Day DL, (Strained left hamstring) |
| 4/4 | Yovani Gallardo | P | Sent to Minors, For Rehabilitation |
| 3/30 | Mike Cameron | CF | Starting to Serve Illegal Substance Suspension |
| 3/27 | Chris Capuano | P | Placed on 15-Day DL, (Sprained ligament, left elbow) |
| 3/26 | Eric Munson | C | Outrighted to Minors |
| 3/25 | Claudio Vargas | P | Released |
| 3/21 | Vinny Rottino | 1B | Sent to Minors |
| 3/21 | Mitch Stetter | P | Sent to Minors |
| 3/21 | Yovani Gallardo | P | Placed on 15-Day DL, (Torn lateral meniscus, left knee) |
| 3/20 | Randy Choate | P | Placed on 15-Day DL, (Fractured left hand) |
| 3/14 | Zach Jackson | P | Sent to Minors |
| 3/11 | Lou Palmisano | | Sent to Minors |
| 3/3 | Scott Cassidy | P | Retired |
| 2/20 | Russell Branyan | 3B | Signed to a Minor League Contract |
| 2/16 | J.J. Hardy | SS | Signed, ( 2008)(avoids arbitration) |
| 2/5 | Dave Bush | P | Signed, ( 2008)(avoids arbitration) |
| 1/23 | Abraham Nunez | 3B | Signed to a Minor League Contract |
| 1/18 | Chris Capuano | P | Signed, ( 2008)(avoids arbitration) |
| 1/16 | Claudio Vargas | P | Signed, ( 2008)(avoids arbitration) |
| 1/15 | Drew Anderson | LF | Designated for Assignment |
| More Transactions |
| Posted Sat Jul 12 23:42:34 EDT 2008 |
