| Date | Player | Pos. | Transaction |
| 5/15 | Jacque Jones | LF | Cleared Waivers and Became a Free Agent |
| 5/13 | Jacque Jones | LF | Released |
| 5/5 | Matt Joyce | LF | Purchased From Minors |
| 5/5 | Jacque Jones | LF | Designated for Assignment |
| 5/3 | Denny Bautista | P | Placed on 15-Day DL, (Right shoulder tendinitis) |
| 5/2 | Dontrelle Willis | P | Sent to Minors, For Rehabilitation |
| 5/1 | Francisco Cruceta | P | Reinstated From Restricted List |
| 4/23 | Clete Thomas | CF | Sent to Minors |
| 4/23 | Curtis Granderson | CF | Removed From 15-Day DL, (Fractured metacarpal, right hand) |
| 4/23 | Curtis Granderson | CF | Recalled From Minors, Rehab Assignment |
| 4/22 | Francisco Cruceta | P | Sent to Minors |
| 4/22 | Francisco Cruceta | P | Reinstated From Restricted List |
| 4/21 | Jordan Tata | P | Sent to Minors |
| 4/21 | Jordan Tata | P | Removed From 15-Day DL, (Right hand fracture) |
| 4/18 | Curtis Granderson | CF | Sent to Minors, For Rehabilitation |
| 4/18 | Francis Beltran | P | Outrighted to Minors |
| 4/17 | Yorman Bazardo | P | Outrighted to Minors |
| 4/16 | Armando Galarraga | P | Called Up from Minors |
| 4/16 | Francis Beltran | P | Designated for Assignment |
| 4/12 | Ryan Raburn | 2B | Called Up from Minors |
| 4/12 | Dontrelle Willis | P | Placed on 15-Day DL, (Hyperextended right knee) |
| 4/11 | Yorman Bazardo | P | Designated for Assignment |
| 4/11 | Clay Rapada | P | Called Up from Minors |
| 4/9 | Casey Fossum | P | Signed to a Minor League Contract |
| 4/6 | Ryan Raburn | 2B | Sent to Minors |
| 4/5 | Francis Beltran | P | Purchased From Minors |
| 3/30 | Clete Thomas | LF | Purchased From Minors |
| 3/30 | Vance Wilson | C | Placed on 15-Day DL, (Recovery from right elbow surgery) |
| 3/30 | Joel Zumaya | P | Placed on 15-Day DL, (Recovery from right shoulder surgery) |
| 3/30 | Jordan Tata | P | Placed on 15-Day DL, (Right hand fracture) |
| 3/30 | Fernando Rodney | P | Placed on 15-Day DL, (Right shoulder tendinitis) |
| 3/30 | Clay Rapada | P | Sent to Minors |
| 3/30 | Aquilino Lopez | P | Purchased From Minors |
| 3/30 | Francisco Cruceta | P | Placed on Restricted List, (visa issues) |
| 3/27 | Freddy Guzman | CF | Outrighted to Minors |
| 3/26 | Tim Byrdak | P | Released |
| 3/25 | Miguel Cabrera | 3B | Signed, ( 2009-2015)(seven-year extension) |
| 3/23 | Curtis Granderson | CF | Placed on 15-Day DL, (Fractured metacarpal, right hand) |
| 3/22 | Miguel Cabrera | 3B | Signed, ( 2009-2016)(eight-year extension) |
| 3/18 | Brent Clevlen | LF | Sent to Minors |
| 3/18 | Virgil Vasquez | P | Sent to Minors |
| 3/12 | Macay McBride | P | Sent to Minors |
| 3/12 | Armando Galarraga | P | Sent to Minors |
| 3/4 | Matt Mantei | P | Retired |
| 2/5 | Armando Galarraga | P | Traded From, Texas (for OF Michael Hernandez) |
| 2/4 | Curtis Granderson | CF | Signed, ( 2008-2012; Opt 2013)(five-year extension) |
| 1/31 | Tony Giarratano | SS | Released |
| 1/18 | Bobby Seay | P | Signed, ( 2008)(avoids arbitration) |
| 1/18 | Miguel Cabrera | 3B | Signed, ( 2008)(avoids arbitration) |
| 1/17 | Marcus Thames | LF | Signed, ( 2008)(avoids arbitration) |
| 1/16 | Nate Robertson | P | Signed, ( 2008-2010)(three-year extension, avoids arbitration) |
| 1/11 | Matt Mantei | P | Signed to a Minor League Contract |
| 1/7 | Francis Beltran | P | Signed to a Minor League Contract |
| 12/20 | Dontrelle Willis | P | Signed, ( 2008-2010)(three-year extension) |
| 12/12 | Chad Durbin | P | Not Offered Contract and Became Free Agent, (non-tendered) |
| 12/12 | Tim Byrdak | P | Signed, ( 2008)(avoids arbitration) |
| 12/7 | Timo Perez | LF | Outrighted to Minors |
| 12/5 | Freddy Guzman | CF | Traded From, Texas (for 1B Chris Shelton) |
| 12/4 | Miguel Cabrera | 3B | Traded From, Florida (for OF Cameron Maybin, eight-player deal) |
| 12/4 | Denny Bautista | P | Traded From, Colorado (for RHP Jose Capellan) |
| 12/4 | Dontrelle Willis | P | Traded From, Florida (for OF Cameron Maybin, eight-player deal) |
| 11/30 | Timo Perez | LF | Designated for Assignment |
| 11/30 | Kenny Rogers | P | Signed as Free Agent, ( 2008) |
| 11/30 | Chris Shelton | 1B | Designated for Assignment |
| 11/30 | Francisco Cruceta | P | Signed as Free Agent, ( 2008) |
| More Transactions |
| Posted Sat May 17 23:27:41 EDT 2008 |
