| Date | Player | Pos. | Transaction |
| 5/14 | Clay Buchholz | P | Placed on 15-Day DL, (Broken nail, right middle finger) |
| 5/14 | Jonathan Van Every | CF | Called Up from Minors |
| 5/12 | Sean Casey | 1B | Recalled From Minors, Rehab Assignment |
| 5/12 | Abe Alvarez | P | Released |
| 5/12 | Sean Casey | 1B | Removed From 15-Day DL, (Right hip flexor strain) |
| 5/12 | Julian Tavarez | P | Designated for Assignment |
| 5/11 | Alex Cora | SS | Recalled From Minors, Rehab Assignment |
| 5/11 | Alex Cora | SS | Removed From 15-Day DL, (Sore right elbow) |
| 5/11 | Jed Lowrie | 2B | Sent to Minors |
| 5/8 | Sean Casey | 1B | Sent to Minors, For Rehabilitation |
| 5/7 | Alex Cora | SS | Sent to Minors, For Rehabilitation |
| 5/5 | Craig Hansen | P | Called Up from Minors |
| 5/5 | Brandon Moss | RF | Placed on 15-Day DL, (Appendectomy) |
| 4/29 | Bryan Corey | P | Designated for Assignment |
| 4/29 | Mike Lowell | 3B | Removed From 15-Day DL, (Sprained left thumb) |
| 4/29 | Mike Lowell | 3B | Recalled From Minors, Rehab Assignment |
| 4/27 | Dan Kolb | P | Released |
| 4/26 | Sean Casey | 1B | Placed on 15-Day DL, (Right hip flexor strain) |
| 4/26 | Brandon Moss | RF | Called Up from Minors |
| 4/25 | Bryan Corey | P | Purchased From Minors |
| 4/25 | Mike Lowell | 3B | Sent to Minors, For Rehabilitation |
| 4/25 | Joe Thurston | 2B | Outrighted to Minors |
| 4/24 | Justin Masterson | P | Purchased From Minors |
| 4/24 | Justin Masterson | P | Sent to Minors |
| 4/23 | Craig Hansen | P | Sent to Minors |
| 4/23 | Craig Hansen | P | Called Up from Minors |
| 4/23 | David Pauley | P | Sent to Minors |
| 4/22 | Bryan Corey | P | Signed to a Minor League Contract |
| 4/22 | David Pauley | P | Called Up from Minors |
| 4/22 | Joe Thurston | 2B | Designated for Assignment |
| 4/17 | Bryan Corey | P | Refused Minor League Assignment - Free Agent |
| 4/17 | Bryan Corey | P | Outrighted to Minors |
| 4/16 | Joe Thurston | 2B | Purchased From Minors |
| 4/15 | Alex Cora | SS | Placed on 15-Day DL, (Sore right elbow) |
| 4/14 | Kyle Snyder | P | Outrighted to Minors |
| 4/11 | Mike Timlin | P | Removed From 15-Day DL, (Contusion, right index finger) |
| 4/11 | Bryan Corey | P | Designated for Assignment |
| 4/11 | Mike Timlin | P | Recalled From Minors, Rehab Assignment |
| 4/10 | Mike Lowell | 3B | Placed on 15-Day DL, (Sprained left thumb) |
| 4/8 | Eric Hull | P | Sent to Minors |
| 4/8 | Eric Hull | P | Traded From, Los Angeles (for IF Christian Lara & cash) |
| 4/7 | Mike Timlin | P | Sent to Minors, For Rehabilitation |
| 4/6 | Josh Beckett | P | Removed From 15-Day DL, (Recurring back spasms) |
| 4/6 | Kyle Snyder | P | Designated for Assignment |
| 3/26 | Brandon Moss | LF | Sent to Minors |
| 3/24 | Josh Beckett | P | Placed on 15-Day DL, (Recurring back spasms) |
| 3/24 | Kevin Cash | C | Purchased From Minors |
| 3/17 | Craig Hansen | P | Sent to Minors |
| 3/13 | Devern Hansack | P | Sent to Minors |
| 3/13 | Curt Schilling | P | Placed on 60-Day DL, (Right biceps degeneration-out 4-6 months) |
| 3/13 | Doug Mirabelli | C | Released |
| 3/8 | David Pauley | P | Sent to Minors |
| 2/25 | Bartolo Colon | P | Signed to a Minor League Contract |
| 2/10 | Kevin Youkilis | 1B | Signed, ( 2008)(avoids arbitration) |
| 2/5 | Bobby Kielty | RF | Signed to a Minor League Contract |
| 2/5 | Matt Miller | P | Signed to a Minor League Contract |
| 2/1 | Sean Casey | 1B | Signed as Free Agent, ( 2008) |
| 1/28 | David Aardsma | P | Traded From, Chi. White Sox (for RHPs Willy Mota & Miguel Socolovich) |
| 1/25 | Kyle Snyder | P | Signed, ( 2008)(avoids arbitration) |
| 1/22 | Dan Kolb | P | Signed to a Minor League Contract |
| 1/22 | Dan Miceli | P | Signed to a Minor League Contract |
| 1/18 | Javier Lopez | P | Signed, ( 2008)(avoids arbitration) |
| 1/11 | Doug Mirabelli | C | Signed as Free Agent, ( 2008) |
| 1/4 | Jon Switzer | P | Signed to a Minor League Contract |
| 1/4 | Scott Atchison | P | Signed to Play in Japan, (sold to Hanshin Tigers) |
| 1/4 | Michael Tejera | P | Signed to a Minor League Contract |
| 12/13 | Kevin Cash | C | Signed to a Minor League Contract |
| 12/13 | Scott Atchison | P | Signed to a Minor League Contract |
| 12/13 | Joe Thurston | 2B | Signed to a Minor League Contract |
| 12/13 | Keith Ginter | 2B | Signed to a Minor League Contract |
| 12/12 | Brendan Donnelly | P | Not Offered Contract and Became Free Agent, (non-tendered) |
| 12/7 | Mike Timlin | P | Signed as Free Agent, ( 2008) |
| 12/1 | Mike Timlin | P | Signed as Free Agent, ( 2008) |
| 11/27 | Lee Gronkiewicz | P | Signed to a Minor League Contract |
| 11/19 | Mike Lowell | 3B | Signed as Free Agent, ( 2008-2010) |
| More Transactions |
| Posted Fri May 16 22:57:57 EDT 2008 |
