Rockets vs. Lakers odds, line: Proven model reveals picks for NBA first round Game 5 matchup on Wednesday, April 29

LeBron James and the Los Angeles Lakers look to close out their NBA Playoffs first round series when they host the Houston Rockets on Wednesday. The Lakers won the first three games in the best-of-7 clash before the Rockets emphatically took Game 4. But now the series heads back to L.A. Kevin Durant (ankle) is out for Houston. Austin Reaves (oblique) is questionable for L.A.

Tipoff is at 10 p.m. ET from Crypto.com Arena in downtown Los Angeles. The latest Rockets vs. Lakers odds list Houston as a 4.5-point favorite at FanDuel Sportsbook. The over/under for total points is 208.5.

Before making any Lakers vs. Rockets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second full week of the 2026 NBA playoffs on a sizzling 25-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Rockets vs. Lakers 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits nearly 60% of the time!

Who wins Lakers vs. Rockets, and which side of the spread hits nearly 60% of the time? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 25-9 roll on top-rated NBA picks!